Dr. Z. Hong Zhou is a Professor of Microbiology, Immunology, and Molecular Genetics and the Founding Director of the Electron Imaging Center for Nanosystems (EICN, at UCLA. Trained as a nuclear physicist at the University of Science and Technology of China, he earned his Ph.D. in biochemistry at Baylor College of Medicine under Wah Chiu and honed his computational skills as a postdoctoral fellow with mathematician Ridgway Scott.
Over the past 30 years, Dr. Zhou has made seminal contributions to infectious disease research and structural biology, focusing on herpesviruses, dsRNA viruses, and protozoan pathogenesis complexes. A pioneer in cryogenic electron microscopy (cryoEM), his group was among the first to demonstrate de novo construction of backbone (Yu et al., Nature 2008) and atomic models (Zhang et al., Cell 2010; Liu et al., Science 2010) of large biological machines using cryoEM alone. Recently, Zhou has advanced cryoEM to study smaller complexes, developing innovative methods like cryoID (Nature Methods 2019) for cellular extracts and IsoNet/spIsoNet (Nature Communications 2022) for in situ cryogenic electron tomography (cryoET). Recent efforts have shifted to protein design and bio-engineering for biomedical applications, taking advantage of his experts in structural biology and discovery research.
With over 320 publications, including more than 30 in Nature, Science, and Cell, Dr. Zhou’s work has garnered ~33,000 citations (h-index 89, i10-index 258; He is a Pew Scholar, Burton Award recipient, and an elected Fellow of the American Academy of Microbiology.